Lawrence Mandarino Lab

Location: Arizona Health Sciences Center, Rm. 6121, 6231, 6105

Professor, Medicine
Division Chief, Division of Endocrinology
Director, UAHS Center for Disparities in Diabetes/Obesity-Metabolism

Arizona Health Sciences Center, Rm. 6121A
Tucson, AZ 85724
(520) 626-8361
mandarino@email.arizona.edu

Academic / Professional Bio:

Dr. Mandarino comes to the UA from Arizona State University where he has served as director of the Center for Metabolic Biology and director of the Mayo/ASU Center for Metabolic and Vascular Biology at Mayo Clinic Arizona. Dr. Mandarino previously spent more than 12 years at the University of Texas Health Science Center at San Antonio in the Departments of Medicine, Biochemistry and Physiology. He has held faculty appointments at the University of Pittsburgh and the University of California, San Diego, after performing a postdoctoral fellowship in endocrinology at the Mayo Clinic. Prior Positions & Appointments Director, Center for Metabolic Biology, Arizona State University (2005-16) Professor of Medicine, College of Medicine, Mayo Clinic, Scottsdale, Ariz. (2010-16) Director, Mayo/ASU Center for Metabolic and Vascular Biology, Mayo Clinic/Arizona State University (2009-16) Professor, School for the Science of Health Care Delivery, Arizona State University (2010-16) Principal Investigator, May Clinic Sangre Por Salud BioBank, Mayo Clinic (2010-16) Professor, Department of Kinesiology, Arizona State University (2005-10) Chair, Department of Kinesiology, Arizona State University (2005-09) Professor, Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas (2000-05) Associate Professor, Department of Physiology, University of Texas Health Science Center (1999-2002) Associate Professor, Departments of Medicine and Biochemistry, University of Texas Health Science Center (1992-2000) Assistant Professor, Departments of Ophthalmology and Physiology, University of Pittsburgh School of Medicine (1987-92) Core Laboratory Director, General Clinical Research Center, University of California, San Diego (1983-87) Assistant Adjunct Professor, Division of Endocrinology and Metabolism, University of California, San Diego (1983-87) Assistant Professor, College of Medicine, Mayo Clinic, Rochester, Minn. (1982-83) Senior Research Fellow, Mayo Clinic, Rochester, Minn. (1981-82) Research Fellow, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minn. (1978-81) Graduate Research Associate, Department of Anthropology, Arizona State University (1977-78) Teaching Assistant, Department of Anthropology, Arizona State University (1972-97) Journal Review & Editorial Activities Metabolism, Ad Hoc Reviewer (1987-present) Journal of Proteome Research, Editorial Board Journal of Clinical Investigation, Ad Hoc Reviewer (1987-present) Journal of Clinical Endocrinology and Metabolism, Ad Hoc Reviewer (1987-present) Diabetologia, Ad Hoc Reviewer (1987-present) Diabetes Care, Ad Hoc Reviewer (1987-present) Diabetes, Ad Hoc Reviewer (1987-present), Editorial Board (2005-13), Associate Editor (2013-15) American Journal of Physiology, Endocrinology and Metabolism, Editorial Board (1998-99)

Research Interests:

Insulin Action Type 2 Diabetes Mellitus Metabolic Syndrome Cell Signaling Exercise Physiology Current Funding NIH/NIDDK, awarded 2012 (period 2012-17), PI; $2,745,389, Molecular Regulation of Muscle Glucose Metabolism (R01DK047936) NIH/NIDDK, awarded 2012 (period 2013-18), PI; $2,475,000, PGC-1 and Muscle Mitochondrial Dysfunction in Diabetes (R01DK066483) NIH/NIDDK, awarded 2012 (period 2012-16), CO-I (Katsanos, PI); $325,797, Regulation of Muscle ATP Synthase Beta Subunit Metabolism in Obesity (R01DK094062) NIH/NIDDK, awarded 2012 (period 2012-17), Co-I (Coletta, PI); $360,903, Epigenetics and the Origin of Muscle Insulin Resistance in Humans (R01DK094013) Completed Research NIH/NIDDK, awarded 2011 (period 2011-14), Co-PI; $450,000, Selenium supplementation and diabetes risk NIH/NIDDK, awarded 2008 (period 2008-13), PI; $2,475,000, PGC-1 and Muscle Mitochondrial Dysfunction in Diabetes (R01DK066483) NIK/NIDDK, awarded 2007 (period 2007-12), PI; $2,690,000, Molecular Regulation of Skeletal Muscle Glucose Metabolism in Man (Continuation of R01DK47936) ABRC, awarded 2006 (period 2006-09), PI; $450,000, Molecular Mechanisms of Lipid Induced Insulin Resistance NIH/NIDDK, awarded 2004 (period 2004-08), PI; $1,875,000, PGC-1 and Muscle Mitochondrial Dysfunction in Diabetes (R01DK066483) NIH/NIDDK, awarded 2003 (period 2003-05), PI; $200,000, Supplement for support for Sara Reyna, PhD, Post-Doctoral Fellow on R01DK47936 NIH/NIDDK, awarded 2002 (period 2002-07), PI; $2,013,000, Molecular Regulation of Skeletal Muscle Glucose Metabolism in Man (Continuation of R01DK47936) NIH/NIDDK, awarded 1998 (period 1998-2001), PI; $791,000, Molecular Regulation of Skeletal Muscle Glucose Metabolism in Man (Continuation of R01DK47936) American Diabetes Association, awarded 1998 (period 1998-2001), PI; $337,500, Insulin Signaling in Human Muscle In Vitro American Diabetes Association, awarded 1996 (period 1996-98), PI; $150,000, Regulation of Glucose Transport in Retinal Capillary Cells NIH/NIDDK, awarded 1994 (period 1994-98), PI; $540,000, Molecular Regulation of Skeletal Muscle Glucose Metabolism in Man (R01DK47936) Juvenile Diabetes Foundation, awarded 1995 (period 1995-97), PI; $150,000, Role of Nonenzymatic Glycosylation in Retinal Capillary Cell Dysfunction NIH/NEI, awarded 1991 (period 1991-95), PI; $781,000, Biochemical Mechanisms of Retinal Capillary Dysfunction (R01EY08398) NIH/NIDDK, awarded 1989 (period 1989-94), PI; $505,000, Pathways of Skeletal Muscule Glucose Metabolism in Man (R01DK41075)