Publications

Publications (updated May 27, 2020)

2020

Duron DI, Lei W, Barker NK, Stine C, Mishra S, Blagg BSJ, Langlais PR, Streicher JM. Inhibition in the Spinal Cord Enhances the Antinociceptive Effects of Morphine by Activating an ERK-RSK Pathway. Sci Signal. 2020 May 5;13(630):eaaz1854. PMID: 32371496. DOI: 10.1126/scisignal.aaz1854

Pendleton AL, Antolic AT, Kelly AC, Davis MA, Camacho LE, Doubleday, K, Anderson MJ, Langlais PR, Lynch RM, Limesand SW. Lower Oxygen Consumption and Complex I Activity in Mitochondria Isolated from Skeletal Muscle of Fetal Sheep with Intrauterine Growth Restriction. Am. J. Physiol. Endocrinol. Metab. 2020 May 12 epub ahead of print. PMID: 32396498. DOI: 10.1152/ajpendo.00057.2020

Napierski NC, Granger K, Langlais PR, Moran HR, Strom J, Touma K, Harris SP. A Novel "Cut and Paste" Method for in Situ Replacement of cMyBP-C Reveals a New Role for cMyBP-C in the Regulation of Contractile Oscillations. Circ. Res. 2020 Mar13;126(6):737-749. PMID: 32078438. DOI: 10.1161/CIRCRESAHA.119.315760

Taylor S-SZ, Jacobsen NL, Pontifex TK, Langlais P, Burt JM. Serine 319 phosphorylation is necessary and sufficient to induce a Cx37 conformation that leads to arrested cell cycling. J. Cell. Sci. 2020 Apr 29;jcs.240721. PMID: 32350069. DOI: 10.1242/jcs.240721

2019

Luo M, Willis WT, Coletta DK, Langlais PR, Mengos A, Ma W, Finlayson J, Wagner GR, Shi CX, Mandarino LJ. Deletion of the Mitochondrial Protein VWA8 Induces Oxidative Stress and an HNF4α Compensatory Response in Hepatocytes. Biochemistry. 2019 Dec 10;58(49):4983-4996. PMID: 31702900. DOI: 10.1021/acs.biochem.9b00863

Pandey R, Zhou M, Islam S, Chen B, Barker NK, Langlais P, Srivastava A, Luo M, Cooke LS, Weterings E, Mahadevan D. Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target. Sci Rep. 2019 Dec 4;9(1):18347. PMID: 31797958. DOI: 10.1038/s41598-019-54545-9

Parker SS, Krantz K, Kwak E, Barker NK, Deer CG, Lee NY, Mouneimne G, Langlais PR. Insulin Induces Microtubule Stabilization and Regulates the Microtubule Plus-End Tracking Protein Network. Molecular and Cellular Proteomics. 2019 July 1; 18 (7) 1363-1381. PMID: 31018989. DOI: 10.1074/mcp.RA119.001450

Rafikov R, McBride ML, Zemskova M, Kurdyukov S, McClain N, Niihori M, Langlais PR, Rafikova O. Inositol monophosphatase 1 as a novel interacting partner of RAGE in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1; 316(3):L428-L444. PMID: 30604625. DOI: 10.1152/ajplung.00393.2018

Jacobsen NL, Pontifex TK, Langlais PR, Burt JM. Phosphorylation-Dependent Intra-Domain Interaction of the Cx37 Carboxyl-Terminus Controls Cell Survival. Cancers (Basel). 2019 Feb 6; 11(2). pii: E188. PMID:30736283. DOI: 10.3390/cancers11020188

Tran L, Langlais PR, Hoffman N, Roust L, Katsanos CS. Mitochondrial ATP synthase β-subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity. Exp Physiol. 2019 Jan; 104(1):126-135. PMID: 30362197. DOI: 10.1113/EP087278

2018

Kras KA, Langlais PR, Hoffman N, Roust LR, Benjamin TR, De Filippis EA, Dinu V, Katsanos CS. Obesity modifies the stoichiometry of mitochondrial proteins in a way that is distinct to the subcellular localization of the mitochondria in skeletal muscle. Metabolism. 2018 Dec; 89:18-26. PMID: 30253140 DOI: 10.1016/j.metabol.2018.09.006

Rafikova O, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikov R. Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2018 Sep; 59(3):334-345. PMID:29652520. DOI: 10.1165/rcmb.2017-0308OC

Suntravat M, Langlais PR, Sánchez EE, Nielsen VG. CatroxMP-II: A Heme-modulated Fibrinogenolytic Metalloproteinase Isolated From Crotalus Atrox Venom. Biometals. 2018 Aug; 31(4):585-593. PMID: 29761254. DOI: 10.1007/s10534-018-0107-5

Willis W, Miranda-Grandjean D, Hudgens J, Willis EA, Finlayson J, DeFilippis E, Zapata Bustos R, Langlais PR, Mielke C, Mandarino LJ. Dominant and sensitive control of oxidative flux by the ATP-ADP carrier in human skeletal muscle mitochondria: Effect of Lysine Acetylation. Arch Biochem Biophys. 2018 Jun 1; 647:93-103. PMID: 29653079. DOI: 0.1016/j.abb.2018.04.006

2017

Kruse R, Krantz J, Barker N, Coletta R, Luo M, Hojlund K, Mandarino LJ, Langlais PR. Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein. Molecular and Cellular Proteomics. 2017 Oct; 16(10):1718-1735. PMID: 28550165. DOI: 10.1074/mcp.RA117.000011

Xie X, Sinha S, Yi Z, Langlais P, Madan M, Bowen BP, Willis W, Meyer C. Role of Adipocyte Mitochondria in Inflammation, Lipemia and Insulin Sensitivity in Humans: Effects of Pioglitazone Treatment. International Journal of Obesity (Lond). 2017 Aug; PMID 29087390. DOI: 10.1038/ijo.2017.192

Peer-reviewed Abstracts (updated May 27, 2020)

2020

Sieffert MM, Keresztes A, Barker N, Langlais PR, Streicher J. Investigation of the Signaling Mechanisms of the Mu-Delta Opioid Receptor Heterodimer. Experimental Biology. San Diego, CA. 2020

Hurtado K, Keresztes A, Barker N, Langlais PR, Streicher J. Does the Mu-Delta Opioid Receptor Heterodimer Repress Akt Kinase to Reduce Opioid Anti-Nociception? Experimental Biology. San Diego, CA. 2020

Gabriel K, Duron D, Barker N, Langlais PR, Streicher J. Does DUSP15 promote activation of ERK MAPK signaling after Hsp90 inhibition in the spinal cord to promote opioid anti-nociception? Experimental Biology. San Diego, CA. 2020

James J, Varghese MV, Niihori M, Zemskova M, Langlais PR, Rafikova O, Rafikov R. The NFU1 G206C mutation metabolically reprograms pulmonary artery smooth muscle cells, promotes proliferation and apoptosis resistance. Annual American Thoracic Society Meeting. Philadelphia, PA. 2020

Kraft M, Francisco D, Childress B, Kimura H, Langlais PR. Significant Differences in Airway Epithelial Cell Phosphorylated Proteins Are Present in Unstimulated Asthma Compared to Cells from Non-Asthmatic Participants. Annual American Thoracic Society Meeting. Philadelphia, PA. 2020

Tabsh KK, Pendleton AL, Barker NK, Langlais PR, Limesand SW, Hill M. Confirmation of Inflammatory Biomarkers from Maternal Plasma in Women with Intrahepatic Cholestasis of Pregnancy. Society for Reproductive Investigation 67th Annual Scientific Meeting. Vancouver, Canada. 2020

Pendleton AL, Davis MA, Kelly AC, Camacho LE, Anderson MJ, Langlais PR, Limesand SW. Decreased Mitochondrial Complex I Activity in Skeletal Muscle of Growth Restricted Ovine Fetuses with Placental Insufficiency. Society for Reproductive Investigation 67th Annual Scientific Meeting. Vancouver, Canada. 2020

2019

James J, Zemskova M, Eccles CA, Varghese MV, Niihori M, Barker NK, Luo M, Mandarino LJ, Langlais PR, Rafikova O, Rafikov R. A single mutation in NFU1 metabolically reprograms pulmonary artery smooth muscle cells and drives proliferation with apoptosis resistance. The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM). 2019

Keresztes A, Olson K, Nguyen P, Barker NK, Liu Z, Langlais PR, Hruby V, Streicher JM. Mu-Delta Opioid Receptor Heterodimer Antagonists: Novel Ligands that Enhance Opioid Analgesia while Reducing Opioid Withdrawal. National Institutes of Health Pain Consortium. Bethesda, MD. 201

Keresztes A, Olson K, Nguyen P, Barker NK, Liu Z, Langlais PR, Hruby V, Streicher JM. The Mu-Delta Opioid Receptor Heterodimer Acts as a Negative Feedback Brake to Reduce Opioid Anti-Nociception by Repression of CaMKII and Src Signaling. International Narcotics Research Conference. New York, NY. 2019

Uhlorn JA, Husband NA, Romero-Aleshire MJ, Moffett CK, Kelly AC, Langlais PR, Nikolich-Zugich J, Brooks HL. Transcriptomic and Proteomic Analysis of CD4+ T Cells to Identify Sex Differences in Angiotensin II Signaling Pathways. American Heart Association – Hypertension 2019 Scientific Sessions. New Orleans, LA. 2019

Dy ABC, Barker NK, Langlais PR, Ledford JG. Identification and Functional Testing of a Novel Receptor for SP-A on Eosinophils. Biology of Acute Respiratory Infection, Gordon Research Conference. Galveston, TX. 2019

Dy ABC, Barker NK, Langlais PR, Ledford JG. Identification and Functional Testing of a Novel Receptor for SP-A on Eosinophils. Annual European Respiratory Society Meeting. Madrid, Spain. 2019

Sangam, S, Gupta A, Yilmaz S, Yuan JX, Langlais PR, Desai AA. Endothelial Targets of Sox17 in Pulmonary Arterial Hypertension: A Quantitative Proteomic Approach. Annual American Thoracic Society Meeting. Dallas, TX. 2019

Langlais PR, Parker SS, Krantz K, Kwak E, Barker NK, Deer CG, Lee NY, Mouneimne. What’s on the Tube? Microtubule-Associated Proteins and Insulin Action. Federation of American Societies for Experimental Biology Science Research Conference Series: The Regulation of Glucose Metabolism Conference. Palm Springs, CA. 2019

Barker NK, Krantz JL, Langlais PR. Characterization of Insulin-Regulated CLASP2 Phosphorylation. 79th Annual American Diabetes Association Meeting. San Francisco, CA. 2019.

Sangam S, Gupta A, Yilmaz S, Yuan JX, Langlais PR, Desai AA. Endothelial Targets of Sox17 in Pulmonary Arterial Hyptertension: A Quantitative Proteomic Approach. Annual American Thoracic Society Meeting. Dallas, TX. 2019

Dy ABC, Barker NK, Langlais PR, Ledford JG. Identification and Functional Testing of a Novel Receptor for SP-A on Eosinophils. Annual European Respiratory Society Meeting. Madrid, Spain. 2019

Dy ABC, Barker NK, Langlais PR, Ledford JG. Identification and Functional Testing of a Novel Receptor for SP-A on Eosinophils. Biology of Acute Respiratory Infection, Gordon Research Conference. Galveston, TX. 2019

Uhlorn JA, Husband NA, Romero-Aleshire MJ, Moffett CK, Kelly AC, Langlais PR, Nikolich-Zugich J, Brooks HL. Transcriptomic and Proteomic Analysis of CD4+ T Cells to Identify Sex Differences in Angiotensin II Signaling Pathways. American Heart Association – Hypertension 2019 Scientific Sessions. New Orleans, LA. 2019

Keresztes A, Olson K, Nguyen P, Barker NK, Liu Z, Langlais PR, Hruby V, Streicher JM. The Mu-Delta Opioid Receptor Heterodimer Acts as a Negative Feedback Brake to Reduce Opioid Anti-Nociception by Repression of CaMKII and Src Signaling. International Narcotics Research Conference. New York, NY. 2019

Keresztes A, Olson K, Nguyen P, Barker NK, Liu Z, Langlais PR, Hruby V, Streicher JM. Mu-Delta Opioid Receptor Heterodimer Antagonists: Novel Ligands that Enhance Opioid Analgesia while Reducing Opioid Withdrawal. National Institutes of Health Pain Consortium. Bethesda, MD. 2019

Pandey R, Zhou M, Islam S, Chen B, Langlais PR, Srivastava A, Cooke LS, Weterings E, Von Hoff D. Mahadevan D. Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target. American Association for Cancer Research Annual Meeting. Atlanta, Georgia. 2019

Tabsh KK, Barker NK, Langlais PR, Hill M. Proteomic Profile of Maternal Plasma in Women with Intrahepatic Cholestasis of Pregnancy. Society for Reproductive Investigation 66th Annual Scientific Meeting. Paris, France. 2019

Tolton A, Addison KJ, Langlais PR, Ledford JG. Determining How SP-A1 and SP-A2 Mediate the Immune Response in Allergic Mouse Models. University of Arizona Undergraduate Biology Research Program. Tucson, AZ. 2019

2018

Lopez-Pier M, Cannon D, Langlais PR, Konhilas JP. AMP activated Protein Kinase and Estrogen-depednent mechanisms underlying increased susceptibility to CVD during Menopause. University of Arizona Biomedical Engineering Student Symposium. Tucson, AZ. 2018

Satyal MK, Bowser S, McMillan RP, Davy BM, Langlais PR, Helm RF, Davy KP, and Hulver MW. Short-Term High-Fat Diet Alters Human Skeletal Muscle ERK 1/2 Phosphorylation. The Obesity Society @ Obesity Week. Nashville, TN. 2018

Haider N, Langlais PR, Moly PK, Barker N, Zhou W. Resistin-induced Differential Global Protein Expression in Human Macrophage. Vascular Discovery: From Genes to Medicine 2018 Scientific Sessions. San Francisco, CA. 2018

Husband NA, Moffett C, Romero-Aleshire MJ, Uhlorn J, Uhrlaub J, Nunez F, Nikolich-Zugich J, Langlais PR, Brooks HL. Angiotensin II-Induced Hypertension in VCD-Treated Menopausal Female Mice Elicits Significant Changes to the Splenic CD4+ Cell Proteome. Experimental Biology Conference. San Diego, CA. 2018

2017

Rafikov R, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikova O. Receptor for Advanced Glycation Endproducts (RAGE) Regulates Metabolic Reprogramming Induced Cver-proliferation in Pulmonary Hypertension. American Thoracic Society International Conference. Washington, DC. 2017

Rafikova O, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikov R. Free Heme-mediated Endothelial Barrier Dysfunction Contributes to the Development of Pulmonary Hypertension. American Thoracic Society International Conference. Washington, DC. 2017

Langlais PR & Mandarino LJ. University of Arizona Department of Medicine Quantitative Proteomics Lab. University of Arizona College of Medicine Junior Investigators Symposium. Tucson, AZ. 2017

Krantz JK, Barker N, Langlais PR. Targeted Quantitative Phosphoproteomics Discovers a Link between the Cytoskeleton-Associated Proteins SOGA1, G2L1, AGAP3, EB1, CLIP2, & MARK2 and the Insulin Signaling Pathway. University of Arizona College of Medicine Junior Investigators Symposium. Tucson, AZ. 2017

Rafikov R, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikova O. Inositol Monophosphate 1 (IMPA1) And Rage Interaction: The Role of Novel Proliferative Pathway in Pulmonary Hypertension. American Heart Association Scientific Sessions. Anaheim, CA. 2017

Rafikova O, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikov R. Hemolysis-mediated Lung Vascular Permeability is Associated with the Development of Pulmonary Hypertension. American Heart Association Scientific Sessions. Anaheim, CA. 2017

Katsanos CS, Kras K, Langlais PR, Willis WT, De Filippis EA, Roust LR. Effects of Obesity on Skeletal Muscle Biological Pathways Associated with Subsarcolemmal Versus Intermyofibrillar Mitochondria Revealed by Proteomics Analysis. 77th Scientific Sessions of the American Diabetes Association. San Diego, CA. 2017

2016

Pauken CM, Langlais PR, Lott, DG. Proteomic Characterization of the Extracellular Matrix Components of Several Laryngeal Cartilages. Gordon Research Conference on Signal Transduction by Engineered Extracellular Matrices. Biddeford, ME. 2016

Pauken CM, Langlais PR, Lott, DG. Proteomic Characterization of the Extracellular Matrix Components of Several Laryngeal Cartilages. 11th ELS Congress. Genoa, Italy. 2016

Kruse-Sorensen R, Krantz J, Barker N, Coletta R, Ricklefs-Johnson K, Luo M, Hojlund K, Mandarino LJ, Langlais PR. To Interact or Not to Interact, That is the Question. The CLASP2 Interactome, a Case Study. 64th American Society for Mass Spectrometry Conference. San Antonio, TX. 2016