Publications

Publications (updated March 15, 2024)

2023

Levine AA, Liktor-Busa E, Balasubramanian S, Palomino SM, Burtman AM, Couture SA, Lipinski AA, Langlais PR, Largent-Milnes TM. Depletion of Endothelial-Derived 2-AG Reduces Blood-Endothelial Barrier Integrity via Alteration of VE-Cadherin and the Phospho-Proteome. Int J Mol Sci. 2023 Dec 30;25(1):531. PMID: 38203706. DOI: 10.3390/ijms25010531

Iannuzo N, Welfley H, Li NC, Johnson MDL, Rojas-Quintero J, Polverino F, Guerra S, Li X, Cusanovich DA, Langlais PR, Ledford JG. CC16 drives VLA-2-dependent SPLUNC1 expression. Front Immunol. 2023 Nov 20:14:1277582. PMID: 38053993. DOI: 10.3389/fimmu.2023.1277582.

Skaria RS, Lopez-Pier MA, Kathuria BS, Leber CJ, Langlais PR, Aras SG, Khalpey ZI, Hitscherich PG, Chnari E, Long M, Churko JM, Runyan RB, Konhilas JP. Epicardial placement of human placental membrane protects from heart injury in a swine model of myocardial infarction. Physiol Rep. 2023 Oct;11(20):e15838. PMID: 37849042. DOI: 10.14814.15838.

Kwak EA, Ahmed T, Cruz Flores P, Ortiz HR, Langlais PR, Mythreye K, Lee NY. Beta IV spectrin inhibits the metastatic growth of melanoma by suppressing VEGFR2-driven tumor angiogenesis. Cancer Med. 2023 Sep;12(18):18981-18987. PMID: 37680049. DOI: 10.1002/cam4.6522.

Ou J, Lewandowski EM, Hu Y, Lipinski AA, Aljasser A, Colon-Ascanio M, Morgan RT, Jacobs LMC, Zhang X, Bikowitz MJ, Langlais PR, Tan H, Wang J, Chen Y, Choy JS. A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations. PLoS Pathog. 2023 Aug 31;19(8):e1011592. PMID 37651467. DOI: 10.1371/journal.ppat.1011592.

Iannuzo N, Dy ABC, Guerra S, Langlais PR, Ledford JG. The Impact of CC16 on Pulmonary Epithelial-Driven Host Responses during Mycoplasma pneumoniae Infection in Mouse Tracheal Epithelial Cells. Cells. 2023 Aug 1;12(15):1984. PMID 37566063. DOI: 10.3390/cells12151984.

Zapata Bustos R, Coletta DK, Galons JP, Davidson LB, Langlais PR, Funk JL, Willis WT, Mandarino LJ. Nonequilibrium thermodynamics and mitochondrial protein content predict insulin sensitivity and fuel selection during exercise in human skeletal muscle. Front Physiol. 2023 Jul 7:14:1208186. PMID 37485059. DOI: 10.3389/fphys.2023.1208186.

Ahmed T, Ramonett A, Kwak EA, Flores PC, Ortiz HR, Langlais PR, Hund TJ, Mythreye K, Lee NY. Endothelial tip/stalk cell selection requires BMP9-induced βIV-spectrin expression during sprouting angiogenesis. Mol Biol Cell. 2023 Jun 1;34(7):ar72. PMID 37126382. DOI: 10.1091/mbc.E23-02-0064.

Jensen CC, Clements AN, Liou H, Ball LE, Bethard JR, Langlais PR, Toth RK, Chauhan SS, Casillas AL, Daulat SR, Kraft AS, Cress AE, Miranti CK, Mouneimne G, Rogers GC, Warfel NA. PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion. J Cell Biol. 2023 Jun 5;222(6):e202208136. PMID 37042842. DOI: 10.1083/jcb.202208136.

Sangam S, Sun X, Schwantes-An TH, Yegambaram M, Lu Q, Shi Y, Cook T, Fisher A, Frump AL, Coleman A, Sun Y, Liang S, Crawford H, Lutz KA, Maun AD, Pauciulo MW, Karnes JH, Chaudhary KR, Stewart DJ, Langlais PR, Jain M, Alotaibi M, Lahm T, Jin Y, Gu H, Tang H, Nichols WC, Black SM, Desai AA. SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics. Am J Respir Crit Care Med. 2023 Apr 15;207(8):1055-1069. PMID 36913491. DOI: 10.1164/rccm.202203-0450OC.

Parker SS, Ly KT, Grant AD, Sweetland J, Wang AM, Parker JD, Roman MR, Saboda K, Roe DJ, Padi M, Wolgemuth CW, Langlais PR, Mouneimne. EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons. J Cell Bio. 2023 May 1;222(5):e202106081. PMID 36828364. DOI: 10.1083/jcb.202106081.

Barakati N, Zapata Bustos R, Coletta DK, Langlais PR, Kohler LN, Luo M, Funk JL, Willis WT, Mandarino LJ. Fuel Selection in Skeletal Muscle Exercising at Low Intensity; Reliance on Carbohydrate in Very Sedentary Individuals. Metab Syndr Relat Disor. 2023 Feb;21(1):16-24. PMID 36328809. DOI: 10.1089/met.2022.0062.

2022

Vizcarra VS, Barber KR, Franca-Solomon G, Majuta L, Smith A, Langlais PR, Largent-Milnes TM, Vanderah TW, Riegel AC. Targeting 5-HT2A receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model. Neurosci Lett. 2022 Oct 15:789:136864.. PMID 36063980. DOI: 10.1016/j.neulet.2022.136864.

Wahl J, Vivek A, Palomino SM, Almuslim M, Cottier KE, Langlais PR, Streicher JM, Vanderah TW, Liktor-Busa E, Largent-Milnes TM. Extracellular alterations in pH and K+ modify the murine brain endothelial cell total and phospho-proteome. Pharmaceutics. 2022 Jul 15;14(7):1469. PMID 35890365. DOI: 10.3390/pharmaceutics14071469.

Ahmed T, Cruz-Flores P, Pan CC, Ortiz HR, Lee YS, Langlais PR, Mythreye K, Lee NY. EPDR1 is a Non-canonical Effector of Insulin-mediated Angiogenesis Regulated by the Endothelial-specific TGF-b Receptor Complex. Journal of Biological Chemistry. 2022 Jul 21:102297. PMID 35872017. DOI: 10.1016/j.jbc.2022.102297.

Cornejo NR, Amofah B, Lipinski A, Langlais PR, Ghosh I, Jewett JC. Direct Intracellular Delivery of Benzene Diazonium Ions As Observed by Increased Tyrosine Phosphorylation. Biochemistry. 2022 Apr 19;61(8):656-664. PMID: 35302352. DOI: 10.1021/acs.biochem.1c00820.

Kwak EA, Pan CC, Ramonett A, Kumar S, Cruz Flores P, Ahmed T, Ortiz HT, Lochhead JJ, Ellis NA, Mouneimne G, Georgieva TG, Lee YS, Vanderah TW, Largent-Milnes T, Mohler PJ, Hund TJ, Langlais PR, Mythreye K, Lee NY. βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling. Nat Commun. 2022. Mar 14;13(1):1326. PMID: 35288568. DOI: 10.1038/s41467-022-28933-1.

Ramonett A, Kwak EA, Ahmed T, Cruz Flores P, Ortiz HR, Lee YS, Vanderah TW, Largent-Milnes T, Kashatus DF, Langlais PR, Mythreye K, Lee NY. Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport. Mol Biol Cell. 2022 Jan 1;33(1):ar4. PMID: 34705526. DOI: 10.1091/mbc.E21-06-0286.

Keresztes A, Olson K, Nguyen P, Lopez-Pier M, Hecksel R, Barker NK, Liu Z, Hruby V, Konhilas J, Langlais PR, Streicher JM. Antagonism of the Mu-Delta Opioid Receptor Heterodimer Enhances Opioid Anti-Nociception by Activating Src and CaMKII Signaling. Pain. 2022 Jan 1;163(1):146-158. PMID: 34252907. DOI: 10.1097/j.pain.0000000000002320.

2021

He S, Ryu J, Liu J, Luo H, Lv Y, Langlais PR, Wen J, Dong F, Sun Z, Xia W, Lynch JL, Duggirala R, Nicholson BJ, Zang M, Shi Y, Zhang F, Liu F, Bai J, Dong LQ. LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance. J Clin Invest. 2021 Dec 15;131(24):e148545. PMID: 34730111. DOI: 10.1172/JCI148545.

Dy ABC, Langlais PR, Barker NK, Addison KJ, Tanyaratsrisakul S, Boitano S, Christenson SA, Kraft M, Meyers D, Bleecker ER, Li X, Ledford JG. Myeloid-associated differentiation marker is a novel SP-A associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. Sci Rep. 2021 Dec 3;11(1):23392. PMID: 34862427. DOI: 10.1038/s41598-021-02869-w.

Levine A, Liktor-Busa E, Lipinski AA, Couture S, Balasubramanian S, Aicher SA, Langlais PR, Vanderah TW, Largent-Milnes TM. Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats. Biol Sex Differ. 2021 Nov 8;12(1):60. PMID: 34749819. DOI: 10.1186/s13293-021-00402-2.

Batty S, Langlais PR. Microtubules in Insulin Action: What’s on the Tube? Trends Endocrinol Metab. 2021 Oct; 32(10):776-789. PMID: 34462181. DOI: 10.1016/j.tem.2021.07.008.

Finlayson J, Barakati N, Langlais PR, Funk J, Zapata Bustos R, Coletta DK, Luo M, Willis WT, Mandarino LJ. Site-specific acetylation of adenine nucleotide translocase 1 at lysine 23 in human muscle. Anal Biochem. 2021 Oct 1; 630:114319. PMID: 34332952. DOI: 10.1016/j.ab.2021.114319.

Polverino F, Wu TD, Rojas-Quintero J, Wang X, Mayo J, Tomchaney M, Tram J, Packard S, Zhang D, Cleveland KH, Cordoba-Lanus E, Owen CA, Fawzy A, Kinney GL, Hersh CP, Hansel NN, Doubleday K, Sauler M, Tesfaigzi Y, Ledford JG, Casanova C, Zmijewski J, Konhilas J, Langlais PR, Schnellmann R, Rahman I, McCormack M, Celli B. Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment. Am J Respir Crit Care Med. 2021 Sep 15;204(6):651-666. PMID: 34033525. DOI: 10.1164/rccm.202012-4510OC.

Casillas AL, Shailender SC, Toth RK, Sainz AG, Clements AN, Jensen CC, Langlais PR, Warfel NA. Direct phosphorylation and stabilization of HIF-1a by PIM1 kinase drives angiogenesis in solid tumors. Oncogene. 2021. Aug; 40(32):5142-5152. PMID: 34211090. DOI: 10.1038/s41388-021-01915-1.

van der Pijl RJ, van den Berg M, van de Locht M, Shen S, Bogaards SJP, Conjin S, Langlais PR, Chen J, Hooijman PE, Labeit S, Heunks LMA, Granzier H, Ottenheijm CAC. MARP1 (Muscle ankyrin repeat protein 1) locks titin to the sarcomeric thin filament and is a newly discovered passive force regulator. J Gen Physiol. 2021 Jul 5; 153(7):e202112925. PMID: 34152365. DOI: 10.1085/jgp.202112925.

Zhang H, Lipinski AL, Smith AF, Moutal A, Khanna R, Langlais PR, Largent-Milnes TM, Vanderah TW. The effects of chronic morphine on the endogenous cannabinoid system in the ventral tegmental area. Front Pharmacol. 2021 Apr 16; 12:632757. PMID: 33953672. DOI: 10.3389/fphar.2021.632757. eCollection.

Zapata-Bustos R, Finlayson J, Langlais PR, Coletta DK, Luo M, Grandjean D, De Filippis EA, Mandarino L. Altered Transcription Factor Expression Responses to Exercise in Insulin Resistance. Front Physiol. 2021 Apr 7; 12:649461. PMID: 33897458. DOI: 10.3389/fphys.2021.649461. eCollection.

Blawn KT, Kellohen KL, Galloway EA, Verkhovsky VG, Wahl J, Vivek A, Barker NK, Cottier KE, Vallecillo TG, Langlais PR, Liktor-Busa E, Vanderah TW, Largent-Milnes TM. Sex hormones regulate NHE1 functional expression and brain endothelial proteome to control paracellular integrity of the blood endothelial barrier. Brain Res. 2021 Jul 15; 1763:147448. PMID: 33771519. DOI: 10.1016/j.brainres.2021.147448.

James J, Zemskova M, Eccles CA, Varghese MV, Niihori M, Barker NK, Luo M, Mandarino LJ, Langlais PR, Rafikova O, Rafikov R. A Single Mutation in NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):734-754. PMID: 33297749. DOI: 10.1161/ATVBAHA.120.314655.

Uhlorn JA, Husband NA, Romero-Aleshire MJ, Moffett C, Lindsey ML, Langlais PR, Brooks HL. CD4+ T cell specific proteomic pathways identified in progression of hypertension across postmenopausal transition. J Am Heart Assoc. 2021 Jan 19;10(2):e018038. PMID: 33410333. DOI: 10.1161/JAHA.120.018038.

2020

James J, Valuparampil VM, Vasilyev M, Langlais PR, Rafikova O, Rafikov R. Complex III Inhibition-Induced Pulmonary Hypertension Affects the Mitochondrial Proteomic Landscape. Int J Mol Sci. 2020 Aug 8;21(16):5683. PMID: 32784406. DOI: 10.3390/ijms21165683.

Moinpour M, Barker NK, Langlais PR, Schwartz JC. Discriminating changes in protein structure using tyrosine conjugation. Protein Sci. 2020 Aug;29(8):1784-1793. PMID: 32483864. DOI: 10.1002/pro.3897.

Duron DI, Lei W, Barker NK, Stine C, Mishra S, Blagg BSJ, Langlais PR, Streicher JM. Inhibition in the Spinal Cord Enhances the Antinociceptive Effects of Morphine by Activating an ERK-RSK Pathway. Sci Signal. 2020 May 5;13(630):eaaz1854. PMID: 32371496. DOI: 10.1126/scisignal.aaz1854

Pendleton AL, Antolic AT, Kelly AC, Davis MA, Camacho LE, Doubleday, K, Anderson MJ, Langlais PR, Lynch RM, Limesand SW. Lower Oxygen Consumption and Complex I Activity in Mitochondria Isolated from Skeletal Muscle of Fetal Sheep with Intrauterine Growth Restriction. Am. J. Physiol. Endocrinol. Metab. 2020 May 12 epub ahead of print. PMID: 32396498. DOI: 10.1152/ajpendo.00057.2020

Napierski NC, Granger K, Langlais PR, Moran HR, Strom J, Touma K, Harris SP. A Novel "Cut and Paste" Method for in Situ Replacement of cMyBP-C Reveals a New Role for cMyBP-C in the Regulation of Contractile Oscillations. Circ. Res. 2020 Mar13;126(6):737-749. PMID: 32078438. DOI: 10.1161/CIRCRESAHA.119.315760

Taylor S-SZ, Jacobsen NL, Pontifex TK, Langlais P, Burt JM. Serine 319 phosphorylation is necessary and sufficient to induce a Cx37 conformation that leads to arrested cell cycling. J. Cell. Sci. 2020 Apr 29;jcs.240721. PMID: 32350069. DOI: 10.1242/jcs.240721

2019

Luo M, Willis WT, Coletta DK, Langlais PR, Mengos A, Ma W, Finlayson J, Wagner GR, Shi CX, Mandarino LJ. Deletion of the Mitochondrial Protein VWA8 Induces Oxidative Stress and an HNF4α Compensatory Response in Hepatocytes. Biochemistry. 2019 Dec 10;58(49):4983-4996. PMID: 31702900. DOI: 10.1021/acs.biochem.9b00863

Pandey R, Zhou M, Islam S, Chen B, Barker NK, Langlais P, Srivastava A, Luo M, Cooke LS, Weterings E, Mahadevan D. Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target. Sci Rep. 2019 Dec 4;9(1):18347. PMID: 31797958. DOI: 10.1038/s41598-019-54545-9

Parker SS, Krantz K, Kwak E, Barker NK, Deer CG, Lee NY, Mouneimne G, Langlais PR. Insulin Induces Microtubule Stabilization and Regulates the Microtubule Plus-End Tracking Protein Network. Molecular and Cellular Proteomics. 2019 July 1; 18 (7) 1363-1381. PMID: 31018989. DOI: 10.1074/mcp.RA119.001450

Rafikov R, McBride ML, Zemskova M, Kurdyukov S, McClain N, Niihori M, Langlais PR, Rafikova O. Inositol monophosphatase 1 as a novel interacting partner of RAGE in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1; 316(3):L428-L444. PMID: 30604625. DOI: 10.1152/ajplung.00393.2018

Jacobsen NL, Pontifex TK, Langlais PR, Burt JM. Phosphorylation-Dependent Intra-Domain Interaction of the Cx37 Carboxyl-Terminus Controls Cell Survival. Cancers (Basel). 2019 Feb 6; 11(2). pii: E188. PMID:30736283. DOI: 10.3390/cancers11020188

Tran L, Langlais PR, Hoffman N, Roust L, Katsanos CS. Mitochondrial ATP synthase β-subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity. Exp Physiol. 2019 Jan; 104(1):126-135. PMID: 30362197. DOI: 10.1113/EP087278

2018

Kras KA, Langlais PR, Hoffman N, Roust LR, Benjamin TR, De Filippis EA, Dinu V, Katsanos CS. Obesity modifies the stoichiometry of mitochondrial proteins in a way that is distinct to the subcellular localization of the mitochondria in skeletal muscle. Metabolism. 2018 Dec; 89:18-26. PMID: 30253140 DOI: 10.1016/j.metabol.2018.09.006

Rafikova O, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikov R. Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2018 Sep; 59(3):334-345. PMID:29652520. DOI: 10.1165/rcmb.2017-0308OC

Suntravat M, Langlais PR, Sánchez EE, Nielsen VG. CatroxMP-II: A Heme-modulated Fibrinogenolytic Metalloproteinase Isolated From Crotalus Atrox Venom. Biometals. 2018 Aug; 31(4):585-593. PMID: 29761254. DOI: 10.1007/s10534-018-0107-5

Willis W, Miranda-Grandjean D, Hudgens J, Willis EA, Finlayson J, DeFilippis E, Zapata Bustos R, Langlais PR, Mielke C, Mandarino LJ. Dominant and sensitive control of oxidative flux by the ATP-ADP carrier in human skeletal muscle mitochondria: Effect of Lysine Acetylation. Arch Biochem Biophys. 2018 Jun 1; 647:93-103. PMID: 29653079. DOI: 0.1016/j.abb.2018.04.006

2017

Kruse R, Krantz J, Barker N, Coletta R, Luo M, Hojlund K, Mandarino LJ, Langlais PR. Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein. Molecular and Cellular Proteomics. 2017 Oct; 16(10):1718-1735. PMID: 28550165. DOI: 10.1074/mcp.RA117.000011

Xie X, Sinha S, Yi Z, Langlais P, Madan M, Bowen BP, Willis W, Meyer C. Role of Adipocyte Mitochondria in Inflammation, Lipemia and Insulin Sensitivity in Humans: Effects of Pioglitazone Treatment. International Journal of Obesity (Lond). 2017 Aug; PMID 29087390. DOI: 10.1038/ijo.2017.192

Peer-reviewed Abstracts (updated March 15, 2024)

2023

Gackle ME, Lu EJ, Goodmanson MJ, Zelms KR, Rojas NG, McGraw M, Nash JC, Lasher JD, Amaro A, Moberly AP, Langlais PR. Assessing Candidate Proteins Identified by Quantitative Proteomics for a Role in Insulin-Stimulated Glucose Uptake. UA Undergraduate Biology Research Program Annual Poster Session. Tucson, AZ. 2024.

Odeneye RE, Lipinski AA, Coletta DK, Langlais PR. Proteomic Profiling of Differentiated Myotubes Identifies Protein Candidates Potentially Involved in Insulin-Stimulated Glucose Uptake. Annual BLAISER Poster Session. Tucson, AZ. 2023.

Grijalva A, Benson D, Fink J, Zhang X, Coletta DK, Langlais PR, Pandey A, Mangiola M, Koevary J, Lancaster J, Goldman S. Immune Modulation to Treat Ischemic Heart Failure. American Heart Association Annual Meeting. Philadelphia, PA. 2023.

Rojas NG, McGraw MB, Nash, JC, Goodmanson MJ, Amaro A, Zelms KR, Gackle ME, Moberly A, Langlais PR. Proteomic Profiling of Mature White Adipocytes Identifies Protein Candidates Potentially Involved in Insulin-Stimulated Glucose Uptake. UA W. A. Franke Honors College Pinnacle Annual Poster Session. Tucson, AZ. 2023.

McGraw MB, Nash, JC, Rojas NG, Amaro A, Gackle ME, Goodmanson MJ, Zelms KR, Moberly A, Langlais PR. New Components of the Insulin Signaling Pathway: Investigating the Role of Novel Proteins in GLUT4 Translocation. UA W. A. Franke Honors College Pinnacle Annual Poster Session. Tucson, AZ. 2023.

Nash, JC, McGraw MB, Rojas NG, Amaro A, Gackle ME, Goodmanson MJ, Zelms KR, Moberly A, Langlais PR. Increased Adipocyte Differentiation Potentially Leading to Increased Expression of Proteins Involved in Glucose Transporter 4 Translocation. UA Undergraduate Biology Research Program Annual Poster Session. Tucson, AZ. 2023.

2022

Hoyer-Kimura C, Konhilas J, Langlais PR, Lopez-Pier M, Salcedo V, Fricks, J. Estrogen Status in Menopause and Sex Differences within the Gut Promote Functionally Distinct Changes. Annual Arizona Physiological Society Meeting. Phoenix, AZ. 2022.

Miller K, Liu X, McSwain M, Laurgui E, Langlais PR, Craig ZR. Effects of a Phthalate Mixture on Hormone and Ovarian Antral Follicle Protein Abundance. Gordon Research Conference: Environmental Endocrine Disruptors. Newry, ME. 2022.

Victor RA, Lipinski A, Langlais PR, Schwartz JC. Identifying novel phase separation proteins in E. coli and human cells using SEC-MS. RNA Society Meeting. Boulder, CO. 2022.

Iannuzo N, Langlais PR, Guerra S, Ledford JG. CC16 DEFICIENCY IMPACTS PULMONARY EPITHELIAL-DRIVEN RESPONSES DURING MYCOPLASMA PNEUMONIAE INFECTION. Aspen Lung Conference. Aspen, Colorado. 2022.

Moberly A, Krantz J, Roman M, Batty S, Surber E, Lee N, Langlais PR. The Role of G2L1 in Microtubule and Actin-based Insulin-Stimulated Delivery of Glucose Transporter 4 to the Plasma Membrane. UA Undergraduate Biology Research Program Annual Poster Session. Tucson, AZ. 2022.

2021

Akram A, Ianuzzo N, Langlais PR, Ledford JG. CC16 Deficiency in Context of Early-life Infections and Epithelial-driven Responses. University of Arizona KEYS Program Symposium. Tucson, AZ. 2021.

Vizcarra, VS, Barber KR, Franca-Solomon G, Smith-Flint A, Lipinski A, Majuta L, Langlais PR, Largent-Milnes TM, Vanderah TW, Riegel AC. Targeted manipulation of PFC 5HT2A receptors and KV7 channels attenuates chronic neuropathic pain in rats. Society for Neuroscience. Virtual. 2021.

Batty S, Roman M, McCrary D, Moberly A, Lipinski A, Barker N, Krantz J, Langlais PR. Identification of a Role for G2L1 in Insulin Action. UA Undergraduate Biology Research Program Annual Poster Session. Tucson, AZ. 2021.

Moberly A, McCrary D, Lipinski A, Roman M, Batty S, Kwak E, Lee N, Langlais PR. Isolation of Microtubules and Microtubule Associated Proteins through Subcellular Fractionation. UA Undergraduate Biology Research Program Annual Poster Session. Tucson, AZ. 2021.

2020

Zapata-Bustos R, Langlais PR, Coletta D, De Filippis EA, Miranda D, Mandarino LJ. Lower response of connective tissue growth factor (CTGF) to exercise characterizes insulin resistant muscle. 80th Annual American Diabetes Association Meeting. Covid-19 USA. 2020.

Sieffert MM, Keresztes A, Barker N, Langlais PR, Streicher J. Investigation of the Signaling Mechanisms of the Mu-Delta Opioid Receptor Heterodimer. Experimental Biology. San Diego, CA. 2020

Hurtado K, Keresztes A, Barker N, Langlais PR, Streicher J. Does the Mu-Delta Opioid Receptor Heterodimer Repress Akt Kinase to Reduce Opioid Anti-Nociception? Experimental Biology. San Diego, CA. 2020

Gabriel K, Duron D, Barker N, Langlais PR, Streicher J. Does DUSP15 promote activation of ERK MAPK signaling after Hsp90 inhibition in the spinal cord to promote opioid anti-nociception? Experimental Biology. San Diego, CA. 2020

James J, Varghese MV, Niihori M, Zemskova M, Langlais PR, Rafikova O, Rafikov R. The NFU1 G206C mutation metabolically reprograms pulmonary artery smooth muscle cells, promotes proliferation and apoptosis resistance. Annual American Thoracic Society Meeting. Philadelphia, PA. 2020

Kraft M, Francisco D, Childress B, Kimura H, Langlais PR. Significant Differences in Airway Epithelial Cell Phosphorylated Proteins Are Present in Unstimulated Asthma Compared to Cells from Non-Asthmatic Participants. Annual American Thoracic Society Meeting. Philadelphia, PA. 2020

Tabsh KK, Pendleton AL, Barker NK, Langlais PR, Limesand SW, Hill M. Confirmation of Inflammatory Biomarkers from Maternal Plasma in Women with Intrahepatic Cholestasis of Pregnancy. Society for Reproductive Investigation 67th Annual Scientific Meeting. Vancouver, Canada. 2020

Pendleton AL, Davis MA, Kelly AC, Camacho LE, Anderson MJ, Langlais PR, Limesand SW. Decreased Mitochondrial Complex I Activity in Skeletal Muscle of Growth Restricted Ovine Fetuses with Placental Insufficiency. Society for Reproductive Investigation 67th Annual Scientific Meeting. Vancouver, Canada. 2020

2019

James J, Zemskova M, Eccles CA, Varghese MV, Niihori M, Barker NK, Luo M, Mandarino LJ, Langlais PR, Rafikova O, Rafikov R. A single mutation in NFU1 metabolically reprograms pulmonary artery smooth muscle cells and drives proliferation with apoptosis resistance. The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM). 2019

Keresztes A, Olson K, Nguyen P, Barker NK, Liu Z, Langlais PR, Hruby V, Streicher JM. Mu-Delta Opioid Receptor Heterodimer Antagonists: Novel Ligands that Enhance Opioid Analgesia while Reducing Opioid Withdrawal. National Institutes of Health Pain Consortium. Bethesda, MD. 201

Keresztes A, Olson K, Nguyen P, Barker NK, Liu Z, Langlais PR, Hruby V, Streicher JM. The Mu-Delta Opioid Receptor Heterodimer Acts as a Negative Feedback Brake to Reduce Opioid Anti-Nociception by Repression of CaMKII and Src Signaling. International Narcotics Research Conference. New York, NY. 2019

Uhlorn JA, Husband NA, Romero-Aleshire MJ, Moffett CK, Kelly AC, Langlais PR, Nikolich-Zugich J, Brooks HL. Transcriptomic and Proteomic Analysis of CD4+ T Cells to Identify Sex Differences in Angiotensin II Signaling Pathways. American Heart Association – Hypertension 2019 Scientific Sessions. New Orleans, LA. 2019

Dy ABC, Barker NK, Langlais PR, Ledford JG. Identification and Functional Testing of a Novel Receptor for SP-A on Eosinophils. Biology of Acute Respiratory Infection, Gordon Research Conference. Galveston, TX. 2019

Dy ABC, Barker NK, Langlais PR, Ledford JG. Identification and Functional Testing of a Novel Receptor for SP-A on Eosinophils. Annual European Respiratory Society Meeting. Madrid, Spain. 2019

Sangam, S, Gupta A, Yilmaz S, Yuan JX, Langlais PR, Desai AA. Endothelial Targets of Sox17 in Pulmonary Arterial Hypertension: A Quantitative Proteomic Approach. Annual American Thoracic Society Meeting. Dallas, TX. 2019

Langlais PR, Parker SS, Krantz K, Kwak E, Barker NK, Deer CG, Lee NY, Mouneimne. What’s on the Tube? Microtubule-Associated Proteins and Insulin Action. Federation of American Societies for Experimental Biology Science Research Conference Series: The Regulation of Glucose Metabolism Conference. Palm Springs, CA. 2019

Barker NK, Krantz JL, Langlais PR. Characterization of Insulin-Regulated CLASP2 Phosphorylation. 79th Annual American Diabetes Association Meeting. San Francisco, CA. 2019.

Sangam S, Gupta A, Yilmaz S, Yuan JX, Langlais PR, Desai AA. Endothelial Targets of Sox17 in Pulmonary Arterial Hyptertension: A Quantitative Proteomic Approach. Annual American Thoracic Society Meeting. Dallas, TX. 2019

Dy ABC, Barker NK, Langlais PR, Ledford JG. Identification and Functional Testing of a Novel Receptor for SP-A on Eosinophils. Annual European Respiratory Society Meeting. Madrid, Spain. 2019

Pandey R, Zhou M, Islam S, Chen B, Langlais PR, Srivastava A, Cooke LS, Weterings E, Von Hoff D. Mahadevan D. Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target. American Association for Cancer Research Annual Meeting. Atlanta, Georgia. 2019

Tabsh KK, Barker NK, Langlais PR, Hill M. Proteomic Profile of Maternal Plasma in Women with Intrahepatic Cholestasis of Pregnancy. Society for Reproductive Investigation 66th Annual Scientific Meeting. Paris, France. 2019

Tolton A, Addison KJ, Langlais PR, Ledford JG. Determining How SP-A1 and SP-A2 Mediate the Immune Response in Allergic Mouse Models. University of Arizona Undergraduate Biology Research Program. Tucson, AZ. 2019

2018

Lopez-Pier M, Cannon D, Langlais PR, Konhilas JP. AMP activated Protein Kinase and Estrogen-depednent mechanisms underlying increased susceptibility to CVD during Menopause. University of Arizona Biomedical Engineering Student Symposium. Tucson, AZ. 2018

Satyal MK, Bowser S, McMillan RP, Davy BM, Langlais PR, Helm RF, Davy KP, and Hulver MW. Short-Term High-Fat Diet Alters Human Skeletal Muscle ERK 1/2 Phosphorylation. The Obesity Society @ Obesity Week. Nashville, TN. 2018

Haider N, Langlais PR, Moly PK, Barker N, Zhou W. Resistin-induced Differential Global Protein Expression in Human Macrophage. Vascular Discovery: From Genes to Medicine 2018 Scientific Sessions. San Francisco, CA. 2018

Husband NA, Moffett C, Romero-Aleshire MJ, Uhlorn J, Uhrlaub J, Nunez F, Nikolich-Zugich J, Langlais PR, Brooks HL. Angiotensin II-Induced Hypertension in VCD-Treated Menopausal Female Mice Elicits Significant Changes to the Splenic CD4+ Cell Proteome. Experimental Biology Conference. San Diego, CA. 2018

2017

Rafikov R, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikova O. Receptor for Advanced Glycation Endproducts (RAGE) Regulates Metabolic Reprogramming Induced Cver-proliferation in Pulmonary Hypertension. American Thoracic Society International Conference. Washington, DC. 2017

Rafikova O, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikov R. Free Heme-mediated Endothelial Barrier Dysfunction Contributes to the Development of Pulmonary Hypertension. American Thoracic Society International Conference. Washington, DC. 2017

Langlais PR & Mandarino LJ. University of Arizona Department of Medicine Quantitative Proteomics Lab. University of Arizona College of Medicine Junior Investigators Symposium. Tucson, AZ. 2017

Krantz JK, Barker N, Langlais PR. Targeted Quantitative Phosphoproteomics Discovers a Link between the Cytoskeleton-Associated Proteins SOGA1, G2L1, AGAP3, EB1, CLIP2, & MARK2 and the Insulin Signaling Pathway. University of Arizona College of Medicine Junior Investigators Symposium. Tucson, AZ. 2017

Rafikov R, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikova O. Inositol Monophosphate 1 (IMPA1) And Rage Interaction: The Role of Novel Proliferative Pathway in Pulmonary Hypertension. American Heart Association Scientific Sessions. Anaheim, CA. 2017

Rafikova O, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikov R. Hemolysis-mediated Lung Vascular Permeability is Associated with the Development of Pulmonary Hypertension. American Heart Association Scientific Sessions. Anaheim, CA. 2017

Katsanos CS, Kras K, Langlais PR, Willis WT, De Filippis EA, Roust LR. Effects of Obesity on Skeletal Muscle Biological Pathways Associated with Subsarcolemmal Versus Intermyofibrillar Mitochondria Revealed by Proteomics Analysis. 77th Scientific Sessions of the American Diabetes Association. San Diego, CA. 2017

2016

Pauken CM, Langlais PR, Lott, DG. Proteomic Characterization of the Extracellular Matrix Components of Several Laryngeal Cartilages. Gordon Research Conference on Signal Transduction by Engineered Extracellular Matrices. Biddeford, ME. 2016

Pauken CM, Langlais PR, Lott, DG. Proteomic Characterization of the Extracellular Matrix Components of Several Laryngeal Cartilages. 11th ELS Congress. Genoa, Italy. 2016

Kruse-Sorensen R, Krantz J, Barker N, Coletta R, Ricklefs-Johnson K, Luo M, Hojlund K, Mandarino LJ, Langlais PR. To Interact or Not to Interact, That is the Question. The CLASP2 Interactome, a Case Study. 64th American Society for Mass Spectrometry Conference. San Antonio, TX. 2016